The PM will tell the Tory faithful the country's "best days lie ahead of us".
She will also announce that fuel duty will be frozen for the ninth year in a row in the Budget later this month.
Her speech comes after Boris Johnson launched a fresh broadside against her Chequers plan for trade with the EU.
The ex-foreign secretary told a packed meeting on Tuesday it was "constitutional outrage" that would lead to the UK being humiliated.
The conference has been overshadowed by tensions over Brexit, with the prime minister sticking by her Chequers plan, which would see the UK retain close links to the EU in trade in goods, but not services, despite criticism from all sides.
Mrs May will be hoping her big keynote speech goes more smoothly than last year when a coughing fit forced her to stop on several occasions and she was also interrupted by a prankster who handed her a mock P45.
Laura Kuenssberg said it was the PM's task to show she could "change the conversation" and demonstrate that Brexit would make a positive difference to people's lives at a time when her future was an "open question" within the party.
She will use her speech to try to strike an optimistic note, and is expected to say: "I passionately believe that our best days lie ahead of us and that our future is full of promise.
"Don't let anyone tell you we don't have what it takes: we have everything we need to succeed."
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