Intel's Brian Krzanich and Under Armour head Kevin Plank have followed Merck's Ken Frazier in leaving the council.
Following mounting pressure, President Trump denounced white supremacists groups on Monday.
A woman was killed on Saturday when a car rammed into a crowd protesting against a white supremacist rally.
After the death, Mr Trump was criticised for not specifically denouncing the far right, instead ascribing blame to "both sides".
'Diversity and inclusion'
Mr Plank sent out a tweet on Monday condemning racism."We are saddened by #Charlottesville. There is no place for racism or discrimination in this world. We choose love & unity."
Ten hours later Mr Plank released another statement on Under Armour's Twitter account announcing his resignation from the advisory body.
"Politics and political agendas have sidelined the important mission of rebuilding America's manufacturing base."
In an earlier tweet, he had also said "there should be no hesitation in condemning hate speech or white supremacy by name".
Both men in the past have expressed some admiration for Mr Trump.
Their resignations follow the departure of Ken Frazier, the head of drug's giant Merck, and one of only a handful of black leaders of Fortune 500 companies, on Monday morning.
In response, Mr Trump tweeted that Mr Frazier would now have "more time to lower rip off drug prices".
In January, Mr Trump had called on pharmaceutical companies to cut "astronomical" drug prices.
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