The facility inside the city state - which has around 1,000 inhabitants - will be profound cleaned, while the crisis room will stay open, representative Matteo Bruni said.
The patient tried positive yesterday.
The center is utilized by clerics, occupants and workers - including those now resigned - just as their family members.
Mr Bruni said the Vatican was connecting with every one of the individuals who had gone through the facility, according to convention.
He gave no subtleties on whether the individual who tried positive was such a worker or among the moderately not many church or watches who live inside its dividers.
The Vatican has said Pope Francis, who dropped a Lent retreat without precedent for his papacy, is experiencing just a chilly that is "without indications identified with different pathologies."

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