An UN council in The Hague is hearing the two-day offer.
The International Criminal Tribunal for the Former Yugoslavia (ICTY) sentenced Karadzic in March 2016.
The ex-pioneer reprimanded the conviction as "political". His legal advisor says he didn't get a reasonable trial however prosecutors need to build his sentence to life.
Previous Bosnian Serb armed force authority Ratko Mladic was condemned to life in jail on comparable charges in November 2017.
The interest began at 09:20 neighborhood time (07:20 GMT). Karadzic and prosecutors will have three hours each to talk.
The Mechanism for International Criminal Tribunals (MICT) will hear the interest. The ICTY was disintegrated in 2017.
A previous specialist, Karadzic was leader of the Bosnian Serb element Republika Srpska amid the Bosnian War in the 1990s.
He was discovered blameworthy of 10 out of 11 tallies of slaughter, atrocities and different barbarities in the contention, including arranging the Srebrenica slaughter of July 1995.
Bosnian Serb warriors butchered about 8,000 Muslim men and young men in a "sheltered zone" ensured by Dutch peacekeeping powers for the UN.
Karadzic is additionally considered in charge of the attack of Sarajevo, which kept going over three years and prompted the passings of 10,000 regular folks.
Nonetheless, he was cleared on one tally of destruction identifying with butcher in seven other Bosnian towns.
Prosecutors trust the ICTY judges "failed in law and actuality", with boss prosecutor Serge Brammertz requesting that the judges "rectify the trial chamber's blunders" and detain Karadzic forever.
Karadzic covered up for a considerable length of time before his inevitable capture in Serbia in 2008.
He took on the appearance of a specialist in elective pharmaceutical, and passed by the name Dr Dragan David Dabic.
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